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Resurgence of Ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days

  1. Sophie Duraffour8,9,*
  1. 1World Health Organization, Conakry, Guinea
  2. 2INSERM U1219, Bordeaux University, Bordeaux, France
  3. 3Bordeaux University Hospital, Bordeaux, France
  4. 4Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK
  5. 5Laboratoire des Fièvres Hémorragiques en Guinée, Hôpital Donka et N'Zérékoré, Conakry, Guinea
  6. 6CDC Guinea Response Team, Conakry, Guinea
  7. 7Center for Global Health, CDC, Atlanta, USA
  8. 8The European Mobile Laboratory Consortium, Hamburg, Germany
  9. 9Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
  10. 10Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital Hills Road, Cambridge, UK
  11. 11School of Public Health, University of Makeni, Sierra Leone
  12. 12Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
  13. 13University of Makeni, Sierra Leone
  14. 14Department of Public Health, University of Makeni, Sierra Leone
  15. 15Department of Biology, University of Rome II 'Tor Vergata', Italy
  16. 16CDC National Center for Emerging and Zoonotic Infectious Diseases, Antlanta, USA
  17. 17Université Gamal Abdel Nasser de Conakry, Laboratoire des Fièvres Hémorragiques en Guinée, Conakry, Guinea
  18. 18PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire
  19. 19Public Health England, Porton Down, Salisbury, UK
  20. 20University of Southampton, South General Hospital, Southampton, UK
  21. 21World Health Organization, Geneva, Switzerland
  22. 22Ministry of Health Guinea, Conakry, Guinea
  23. 23Institute for Evolutionary Biology, Centre for Infection, Immunity & Evolution, Ashworth Laboratories, University of Edinburgh, Edinburgh, EH9 3FL, UK
  1. *Corresponding author: Sophie Duraffour, Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany, Phone: +49 40 42818 940, Fax: +49 40 42818 931, e-mail: sophieduraffour{at}
  1. # These authors contributed equally.


We report on an Ebola virus disease (EVD) survivor who showed Ebola virus (EBOV) in seminal fluid 531 days after onset of disease. The persisting virus was sexually transmitted in February 2016, about 470 days after onset of symptoms, and caused a new cluster of EVD in Guinea and Liberia.

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This Article

  1. Clin Infect Dis. doi: 10.1093/cid/ciw601
  1. This article is Open AccessOA
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